Research Findings

Incidence Studies - Liver Cancer

Tobacco, alcohol use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project (2018)
 In a pooled analysis of 1.52 million adults from 14 U.S. cohort studies, increased risks for both hepatocellular carcinoma (HCC; 1,423 cases) and intrahepatic cholangiocarcinoma (ICC; 410 cases) were associated with cigarette smoking and heavy alcohol consumption at baseline. Smoking cessation and light-to-moderate drinking were associated with reduced risk for HCC but not ICC.
Body Mass Index, Diabetes and Intrahepatic Cholangiocarcinoma Risk: The Liver Cancer Pooling Project and Meta-analysis (2018)
 Based on a pooled analsis of 1.54 million individuals from 13 prospective studies, risk for intrahepatic cholangiocarcima (n=414 cases) was 62% higher in the obese and 81% greater in those with a history of diabetes. Similar findings were observed in a separate meta-analysis of 14 studies identified through a systematic review of the literature.
Body Mass Index, Waist Circumference, Diabetes, and Risk of Liver Cancer for U.S. Adults (2016)
 In a pooled analysis of 1.57 million adults from 14 U.S. cohort studies, liver cancer (n=2,162 cases) risk was associated with greater BMI, greater waist circumference, and history of diabetes, although the BMI association was limited to those who were sera-negative for hepatitis.
Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: results from the Liver Cancer Pooling Project (2015)
 In a pooled analysis of 11 prospective cohorts, liver cancer risk was elevated in women who had bilateral-oophorectomy, but was not associated with oral contraceptive use, parity, age at first birth, age at natural menopause, or duration of fertility.
Coffee consumption and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma by sex: The Liver Cancer Pooling Project (2015)
 A pooled study of 11 cohorts reported a decreased risk for hepatocellular carcinoma with increased coffee consumption, especially in women, but no association for intrahepatic cholangiocarcinoma with coffee consumption.
NSAID use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The Liver Cancer Pooling Project (2015)
 In a pooled analysis of 10 cohort studies, hepatocellular carcinoma risk was reduced with current aspirin use, but not associated with Ibuprofen use.