|
|
Important Research Findings
| Papillary thyroid cancer and polymorphic variants in TSHR- and RET-related genes: A nested case-control study within a cohort of US radiologic technologists
(2007
) | | | In a study of 167 papillary thyroid cancer cases and 491 control subjects, we observed no statistically significant associations with 10 selected polymorphic variants. A suggested association was seen with one variant in the RET signaling pathway.
| | | [Abstract] [PubMed] | | | | DNA damage among thyroid cancer and multiple cancer cases, controls, and long-lived individuals
(2005
) | | | We tested for DNA damage in lymphoblastoid cells from persons who had multiple cancer diagnoses (breast cancer and another cancer site), thyroid cancer, early-onset breast cancer and two control groups unaffected by cancer: one group was about the same age as those who had cancer and the other group was long-lived with no cancer in their relatives. The Comet Assay was used to detect the amount of DNA damage in the cells. Damage to the DNA did not appear to be consistently higher among those women with early-onset breast cancer, however those with thyroid and multiple cancers appeared to show more DNA damage when compared to the control group matched by age. For the long-lived control group, the amount of DNA damage appeared to be even lower than the age-matched controls, but the difference was not statistically significant because the numbers in the long-lived group were small. Nevertheless, the pattern detected seemed to indicate that DNA damage was highest in the cancer cases, less in controls, and suggestively lower in those who were long-lived with no family cancer history.
| | | [Abstract] [PubMed] | | |
|
